I recently upgraded to Creative Cloud and have discovered that the Twain nor any other plug-ins will run in Photoshop CS 6 on a Apple Computer running OS X 10.8. My understanding is it's related to Photoshop not able to recognize plug-ins in 64 bit mode, but can in 32 bit mode. And since Apple platforms only run in 64 bit it is not possible. Was suggested to use the Imagekit from Photoshop but people are having problems with that as well. Would like to see this be fixed so that everyone who likes to scan direct into Photoshop can.