I go to open a file, or create a new one, and nothing happens. This is incredibly annoying and I can't get any work done. I've tried reinstalling. I've tried compatability modes. I've tried a bunch of stuff, so wtf?
»a bunch of stuff« is not exactly very clear ...
Please read this and proceed accordingly (restoring Preferences after making sure all customized presets like Actions, Patterns, Brushes etc. have been saved might be of special interest):
http://blogs.adobe.com/crawlspace/201...
If nothing helps you may want to provide more information (version, OS, hardware, ...).