Have you tried launching the application and letting it sit for a while? There could be background tasks that are slowing things down.
Now, assuming THAT isn't the problem, it could be that your system font cache was corrupted during the upgrade. This is actually surprisingly common. Clearing your PS cache won't help because system cache corruption will "reinfect" the Photoshop (or Illustrator, whatever) cache. Now, it might not be the cause, but that would explain multiple apps crashing.