I use Lightroom CC on a MacBook Pro with German keyboard layout but with the system language set to English. I also like to set all software user interfaces to English. If I do so for Lightroom CC, not only the user interface language changes, but also the keyboard shortcuts switch to the ones suitable for English keyboard layouts. Example: For zooming in the shortcut "cmd + #" is not longer working, I now have to press "shift + cmd + =", which on an English keyboard would be equal to "cmd + #". This is really annoying and quite forces me to use a German user interface in order to work comfortable.