This conversation has been merged. Please reference the main conversation: Photoshop 21.1: Every drawing action (Painting/selections) snaps to upper left hand screen corner (Windows 7/Window 10 with WinTab)
I do not see the problem with a pen/tablet, OR when smoothing is > 0%
The clone and smudge tools do not have a smoothing setting so they show the problem all of the time with the mouse (but not with a pen).
Desktop PC - AMD processor with old Graphics card. Acceleration on or off makes no difference.
Windows 10 (1909). Photoshop CC 21.1.0 (tested on PS CC 20.0.8 on same PC - no problems found)
Tablet = XP-PEN G640S .... I have replicated the problem with the tablet removed (but the drivers were still loaded)