I was working in a layered PSD file I had opened. I added work,layers. Saved it. Flattened it. Saved it as a JPG. Cropped that JPG and saved it. Closed the JPG. The next time I opened the PSD file, all my work was cropped off like I had cropped the JPG. AND the newest layers and work were gone as if I had done nothing after opening it the first time.
I am now using CS5.1. At least it works right.